The population of the Earth almost disappeared as a result of a pandemic caused by a mutated fungus. The disease causes irreversible changes in the human body, a person loses his mind and behaves aggressively, like a zombie. Civilization no longer exists, few survivors live in isolation under the protection of the military. Cities outside the zones are dangerous ruins inhabited by infected people and people who have almost lost humanity. Heroes, the smuggler Joel and teenage girl Ellie, are trying to cross the continent, colliding in depopulated cities with all the set of dangers. The game requires hidden actions, the combat capability and the number of ammunition of the heroes are small, and it is best for them to avoid fighting. For most of the game, the player controls Joel, while Ellie and Joel's other companions are controlled by artificial intelligence.